Natural products are the cornerstone of our group. Within the broad study of natural products chemistry there are three primary areas of inquiry; total synthesis, reaction development, and molecular pharmacology. Typical targets selected for total synthesis possess structures that, from a synthetic chemistry point of view, have atom connectivity challenges. In addressing these challenges within specific targets, inspiration may be gained for new synthetic methods. Our goal is to develop new methods to compliment and improve upon existing reactions. Accordingly, emphasis is placed on the development of reactions that are generally applicable to synthesis, as it is most broadly defined. The second area of focus and inquiry in our group is the study of natural products that are biologically relevant in selected fields of biology and medicine. Through interdisciplinary collaborations, we will study optimization of the biological performance and/or investigation into the mechanism action of the natural products prepared in our laboratory. Information gained through these collaborations will determine the future direction of the projects undertaken.